Pharmaceutical & Biotech

Leverage Rocky DEM tools to improve pharmaceutical safety and quality while reducing development, experimentation, regulatory approval, and manufacturing costs.

Overview

Developing a new medicine is a long, expensive cycle. Optimizing available resources to achieve regulatory approval is critical.

DEM simulation can be used in a variety of ways to enhance the drug development process. Virtual analysis greatly adds to insight, capturing dynamic interactions between process, geometry, and material variables.  The result is significant process improvement with reduced reliance on experimental testing.

Any information gleaned can help engineers make informed decisions on formulation, process, scale-up, equipment design changes, and troubleshooting.

Applications applications

Coating

Simulate real-scale equipment using custom polyhedral particles that model pill/tablet coating processes, including covering homogeneity.

  • Polyhedral elements

    Accurately predict dynamic bulk behavior of tablets and pills. Polyhedron models eliminate artificially bumpy surfaces that can significantly affect particle dynamics.

  • Collision statistics

    Improve equipment design to reduce breakage via collision statistic data analysis.

  • CFD–DEM coupling

    Run coupled Rocky–Ansys Fluent simulation during the coating process to account for convective heat transfer with hot/cold airflow.

  • Liquid film modeling

    Model liquid-film-spray injection and drying to evaluate coating homogeneity system-wide — all while accounting for liquid-bridge adhesion forces.

Thermal Coater

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Tablet Coater

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Drying and Heat Exchange

Rocky DEM particle simulation accurately models both conductive and convective heat exchange — as well as drying processes — for bulk materials.

  • CFD–DEM coupling

    Rocky–Ansys Fluent coupled simulations enable analysis of convective heat transfer between particles and fluid.

  • True physical representations

    Increase simulation accuracy with realistic particle shapes that account for collisions and fluid forces.

  • Multi-GPU processing

    Leverage multi-GPU capabilities to handle huge cases with millions of particles.

  • Liquid film modeling

    Model liquid-film spray injection and drying processes to evaluate system-wide coating homogeneity — all while accounting for liquid-bridge adhesion forces.

Thermal Coater

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Mixing and blending

Rocky DEM accurately predicts mixing- and blending-equipment efficiency, enabling increased batch sizes, reduced blending times, and minimal segregation.

  • Greater productivity

    Optimize mixing-device design to reduce blending time and increase productivity.

  • Upscale equipment

    Upscale equipment
Apply DEM to evaluate the best upscaling strategy, from lab to commercial.

  • Add complex motions

    Simulate complex, combined-geometry motions using Rocky DEM’s fully integrated motion kernel.

V Blender

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Plow Mixer

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Ring Pan Mixer

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System scale-up

Select the best scale-up strategy, from laboratory to commercial, by modeling particle-level mechanisms that influence resulting granule properties.

  • True physical representations

    Increase simulation accuracy using realistic particle shapes that account for collisions and fluid forces.

  • Multi-GPU processing

    Leverage multi-GPU capabilities to handle million-particle commercial cases, enabling a closer match to actual size.

  • Add complex motions

    Simulate complex, combined geometry motions using Rocky DEM’s fully integrated motion kernel.

  • Enhanced post-processing

    Rocky DEM capabilities enable easy information extraction for comparison with experimental results — from particle-level stresses to residence time distribution.

150 L Commercial Scale Granulator

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Controlling Discharge

Rocky DEM simulates real-world bulk-flow regulation, helping to keep flow rates at levels appropriate to the process.

  • Realistic particle shapes

    Accurately predict bulk material dynamic behavior using polyhedral or shell particles.

  • Improve hopper discharge

    Evaluate discharge flow patterns to both eliminate stagnant zones and mitigate degrading-material problems.

  • Evaluate feeders and valves

    Optimize valve/feeder designs for uniform hopper drawdown.

Vibrating spiral conveyor

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Rotary Valve

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Webinar

Discover how Rocky DEM simulations can help improve pharmaceutical equipment designs

  • Tablet Coating Operation

    Discover how DEM simulations can be used to predict tasks like tablet mixing in a coating operation.

  • Post-processing capabilities

    Examine critical process output parameters for design optimization and risk mitigation during operations, improving pharmaceutical equipment design.

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